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Highlights

Chemically targeting clots to increase retention in the injured brain

ECM targeting enhances nanosensors

Nanosensors that detect protease activity in traumatic brain injury

ACS Sensors Rising Stars in Sensing

Publications

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  1. S Han, W Yoo, O Carton, J Joo, EJ Kwon. PEGylated Multimeric RNA Nanoparticles for siRNA Delivery in Traumatic Brain Injury. Small, 2024. Accepted.
  2. MI Madias, LN Stessman, SJ Warlof, JA Kudryashev, EJ Kwon. Spatial Measurement and Inhibition of Calpain Activity in Traumatic Brain Injury with an Activity-Based Nanotheranostic Platform, 2024. ACS Nano, accepted. [ Open Access]
  3. RM Kandell, JR Wu, EJ Kwon. Reprogramming clots for in vivo chemical targeting in traumatic brain injury. Advanced Materials, 2024. Accepted. [ Open Access]
  4. M Tong, N Palmer, A Dailamy, A Kumar, H Khaliq, S Han, E Finburgh, M Wing, C Hong, Y Xiang, K Miyasaki, A Portell, J Rainaldi, A Suhardjo, S Nourreddine, WL Chew, EJ Kwon, P Mali. Robust genome and cell engineering via in vitro and in situ circularized RNAs, 2024. Nature Biomedical Engineering, accepted.
  5. JC Schmock, M Jain, LA Street, AT Tankka, D Schafer, H Her, S Elmsaouri, ML Gosztyla, EA Boyle, P Jagannatha, E Luo, EJ Kwon, M Javonovic, GW Yeo. Large-scale evaluation of the ability of RNA-binding proteins to activate exon inclusion. Nat Biotech, 2024. [ Open Access]
  6. MD Diaz*, RM Kandell*, JR Wu, A Chen, KL Christman†, EJ Kwon†. Infusible Extracellular Matrix Biomaterial Promotes Vascular Integrity and Modulates the Inflammatory Response in Acute Traumatic Brain Injury. Advanced Healthcare Materials, 2023. [ Open Access ]
  7. JA Kudryashev, MI Madias, RM Kandell; QX Lin, EJ Kwon†. An Activity-Based Nanosensor for Minimally-Invasive Measurement of Protease Activity in Traumatic Brain Injury. Advanced Functional Materials, 2023. [ Open Access ]
  8. JR Wu, Y Hernandez, KF Miyasaki, EJ Kwon†. Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain. Advanced Drug Delivery Reviews, 114820. [ Open Access ]
  9. MT Spang, R Middleton, M Diaz, J Hunter, J Mesfin, A Banka, H Sullivan, Wang R, TS Lazersn, S Bhatia, J Corbitt, G D’Elia, G Sandoval-Gomez, R Kandell, MA Vratsanos, K Gnanasekaran, T Kato, S Igata, C Luo, KG Osborn, N Gianneschi, O Eniola-Adefeso, P Cabrales, E Kwon, F Contijoch, RR Reeves, AN Demaria, KL Christman. Healing Tissues From the Inside Out: Infusible Extracellular Matrix Biomaterial for Targeting and Treating Inflammatory Tissues via Intravascular Administration. Nature Biomedical Engineering, 2023, 7 (2), 94-109.
  10. LE Waggoner, KF Miyasaki, EJ Kwon†. Analysis of PEG-lipid Anchor Length on Lipid Nanoparticle Pharmacokinetics and Activity in a Mouse Model of Traumatic Brain Injury. Biomaterials Science, 2023, 11, 4238 - 4253. [ Open Access ]
  11. A Almenar-Queralt; RS Chaves; EJ Kwon; SB Shah. Heads Up! Interlinked Amyloidogenic and Axonal Transport Pathways in Concussion-induced Neurodegeneration. Neuroscience Insights, 2022.
  12. Waggoner, LE; Kang, JY; Zuidema, J; Hurtado, AA; Vijaykumar, S; Sailor, MJ; Kwon, EJ†. Porous Silicon Nanoparticles Targeted to the Extracellular Matrix for Therapeutic Protein Delivery in Traumatic Brain Injury. Bioconjugate Chemistry, 2022. ACS Editors' Choice Article.
  13. Kandell RM*, Kudryashev JA*, Kwon EJ. Targeting the Extracellular Matrix in Traumatic Brain Injury Increases Signal Generation from an Activity-Based Nanosensor. ACS Nano, 2021, 15(12): 20504-20516.
  14. Waggoner LE, Madias MI, Hurtado AA, Kwon EJ. Pharmacokinetic analysis of peptide-modified nanoparticles with engineered physicochemical properties in a mouse model of traumatic brain injury. AAPS Journal, 2021, 23(5), 1-12.
  15. Chan LW, Hern KE, Ngambenjawong C, Lee K, Kwon EJ, Hung DT, Bhatia SN. Selective Permeabilization of Gram-Negative Bacterial Membranes Using Multivalent Peptide Constructs for Antibiotic Sensitization. ACS Infectious Diseases, 2021, 7(4), 721-732.
  16. Kwon EJ*†, Ko H*, Bhatia SN. Peptide Spiders: Peptide-Polymer Conjugates to Traffic Nucleic Acids. Mol Pharm., 2020, 17 (9), 3633-3642.
  17. Kandell RA*, Waggoner LE*, Kwon EJ. Nanomedicine for Acute Brain Injuries: Insight from Decades of Cancer Nanomedicine. Mol Pharm., 2020. 10.1021/acs.molpharmaceut.0c00287
  18. Kudryashev JA, Waggoner LE, Leng HT, Mininni NH, Kwon EJ. An Activity-Based Nanosensor for Traumatic Brain Injury. ACS Sensors, 2020, 5 (3), 686-692. Rising Stars in Sensing.
  19. Bertucci A, Kim KH, Kang J, Zuidema JM, Lee S, Kwon E, Kim D, Howell SB, Ricci F, Ruoslahti E, Jang HJ, Sailor MJ. Tumor-targeting, microRNA-silencing Porous Silicon Nanoparticles for Ovarian Cancer Therapy. ACS Applied Materials & Interfaces, 2011(27), 23926-23937.
  20. Lo JH, Hao L, Muzumdar MD, Raghavan S, Kwon EJ, Pulver EM, Hsu F, Aguirre AJ, Wolpin BM, Fuchs CS, Hahn WC, Jacks T, Bhatia SN. iRGD-guided tumor-penetrating nanocomplexes for therapeutic siRNA delivery to pancreatic cancer. Molecular Cancer Therapeutics, 17(11): 2377-2388.
  21. Kwon EJ, Skalak M, Bertucci A, Braun G, Ruoslahti E, Sailor MJ, Bhatia SN. Porous Silicon Nanoparticle Delivery of Tandem Peptide Anti-infectives for the Treatment of P. aeruginosa Lung Infections. Advanced Materials, 2017, 29(35).
  22. Kwon EJ*, Dudani JS*, Bhatia SN. Ultrasensitive tumour-penetrating nanosensors of protease activity. Nature Biomedical Engineering, 2017, 1: 0054.
  23. Lo JH*, Kwon EJ*, Zhang AQ, Singhal PS, Bhatia SN. A comparison of modular PEG incorporation strategies for stabilization of peptide-siRNA nanocomplexes. Bioconj Chem, 2016, 27(10): 2323-2331.
  24. Kwon EJ, Skalak M, Lo Bu R, Bhatia SN. A Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries. ACS Nano, 2016, 10 (8), 7926–7933.
  25. Kang J, Joo J, Kwon EJ, Skalak M, Hussain S, She Z, Ruoslahti E, Bhatia SN, Sailor MJ. Self-sealing prous silicon-calcium silicate core-shell nanoparticles for targeted siRNA delivery to the injured brain. Advanced Materials, 2016, 28(36), 7962-7969.
  26. Joo J, Kwon EJ, Kang J, Skalak M, Anglin EJ, Mann AP, Ruoslahti E, Bhatia SN, Sailor MJ. Porous silicon-graphene oxide targeted delivery of siRNA to the injured brain. Nanoscale Horizons. 2016,1, 407-414.
  27. Mann AP, Scodeller P, Hussain S, Joo JM, Kwon EJ, Braun G, Molder T, She ZG, Kotamraju V, Ranscht B, Krajewski S, Teesalu T, Bhatia SN, Sailor MJ, Ruoslahti E. A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries. Nat Commun, 2016; 7:11980.
  28. Kwon EJ, Lo JH, Bhatia SN. Smart Nanosystems: Bio-inspired Technologies that Interact with the Host Environment. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14460-6.
  29. Siegert S, Seo J, Kwon EJ, Rudenko A, Cho S, Wang W, Flood Z, Martorell AJ, Ericsson M, Mungenast AE, Tsai LH. The schizophrenia risk gene product miR-137 alters presynaptic plasticity. Nat Neurosci. 2015, 18(7):1008-16.
  30. Lin KY, Kwon EJ, Lo JH, Bhatia SN. Drug-induced amplification of nanoparticle targeting to tumors. Nanotoday. 2014, 9(5):550-559.
  31. Wang W, Kwon EJ, Tsai LH. MicroRNAs in learning, memory, and neurological diseases. Learning and Memory. 2012, 19(9):359-368.
  32. Kwon EJ, Wang W, Tsai LH. Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets. Mol Psychiatry. 2011, 18(1):11-2.
  33. Kwon EJ, Liong S, Pun SH. A truncated HGP peptide sequence that retains endosomolytic activity and improves gene delivery efficiency. Mol Pharm. 2010, 7(4):1260-5.
  34. Kwon EJ, Lasiene J, Jacobson BE, Park IK, Horner PJ, Pun SH. Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials. 2010, 31(8):2417-24.
  35. Kwon EJ, Bergen JM, Park IK, Pun SH. Peptide-modified vectors for nucleic acid delivery to neurons. J Control Release. 2008, 132(3): 230-235.
  36. Kwon EJ, Bergen JM, Pun SH. Application of an HIV gp41-derived peptide for enhanced intracellular trafficking of synthetic gene and siRNA delivery vehicles. Bioconjug Chem. 2008, 19(4):920-7.
  37. Bergen JM, Kwon EJ, Shen TW, Pun SH. Application of an environmentally sensitive fluorophore for rapid analysis of the binding and internalization efficiency of gene carriers. Bioconjug Chem. 2008, 19(1):377-84.
  38. Cellitti J, Llinas M, Echols N, Shank EA, Gillespie B, Kwon E, Crowder SM, Dahlquist FW, Alber T, Marqusee S. Exploring subdomain cooperativity in T4 lysozyme I: structural and energetic studies of a circular permutant and protein fragment. Protein Sci. 2007 May;16(5):842-51.

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