Targeted Nanoscale Delivery to the Brain
The greater majority of therapeutics for application in the brain are not targeted to specific cells or structures, leading to decreased efficacy and/or off-target activity. Our goal is to create nanomaterial platforms for "targeted pharmacology" where the surface of nanomaterials is engineered to interact with specific biological structures and carries a diagnostic or therapeutic payload. In order to mediate this interaction of synthetic nanomaterials and biological structures, we are particularly interested in using peptides. Peptides are small biological units that can be readily synthesized and incorporated into nanomaterials. In addition to the modification of nanomaterials with peptides, we are also interested in the discovery of new peptides that have unique properties and function.